9/25/2005

CX717

From Wikipedia, the free encyclopedia.

CX717 was created by Dr Gary Lynch from the University of California. CX717 is part of a family of compounds called ampakines which work by boosting the brain chemical glutamate responsible for learning and recall.

In 2005 The U.S. Food and Drug Administration (FDA) accepted Cortex Pharmaceuticals' IND (Investigational New Drug) application to initiate pilot Phase II clinical trials in the United States.


  • Facilitation of Task Performance and Removal of the Effects of Sleep Deprivation by an Ampakine (CX717) in Nonhuman Primates



  • Effects of the potent ampakine CX614 on hippocampal and recombinant AMPA receptors: interactions with cyclothiazide and GYKI 52466



  • Dr. Gary Lynch



  • PT-141

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    From:
  • wikipedia article


  • PT-141 is a new medication for use in treating sexual dysfunction in men (erectile dysfunction or impotence) as well as sexual dysfunction in women (sexual arousal disorder). It seems to be the first real aphrodisiac. Unlike Viagra and other related medications, it does not act upon the vascular system, but directly increases sexual desire. PT-141 is a spray introduced nasally.

    Originally, the compound Melanotan II that PT-141 was developed from was tested as a sunless tanning agent. Melanotan II did induce tanning, accompanied by sexual arousal and spontaneous erections for male volunteers as unexpected side effects. In clinical studies, PT-141 has been shown to be effective in treating male erectile dysfunction and female sexual dysfunction. It is produced by Palatin Technologies.

    PT-141 is a cyclic hepta-peptide lactam analog of alpha-melanocyte-stimulating hormone (alpha-MSH) that activates the melanocortin receptors MC3-R and MC4-R in the central nervous system. It has the amino acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH or cyclo-[Nle4, Asp5, D-Phe7, Lys10]alpha-MSH-(4-10). PT-141 is a metabolite of Melanotan II that lacks the C-terminal amide function.

    titanium boron lithium perchlorate intermetallic high-temperature fill

    From:
  • globalsecurity.org


  • The munition uses 300 lb (136kg) of a two-stage reactive and pelletised mix of "titanium boron lithium perchlorate intermetallic high-temperature fill" that burns at 1,000ºF for a long time and with low overpressure so any remnants are not ejected from the facility. As a by-product of the HTI reaction, 35 lb (15.8kg) of disinfecting monatomic chlorine and monatomic fluorine gas, along with hydrochloric and hydrofluoric acid, will be left to destroy any remaining BW agents.